Showing posts with label Singapore. Show all posts
Showing posts with label Singapore. Show all posts

Indonesian MOH Announces Bird Flu Fatality

 

 

 

# 6420

 

 

The Indonesian Ministry of Health has posted a fairly detailed account of their 190th H5N1 infection, that of an 8 year-old girl from Falkirk District, West Java who died on July 3rd. 

 

 

The girl (initials K.K.) initially developed a fever on June 18th – five days after reported contact with poultry at a live market near her home – and while on holiday in Singapore with her family was diagnosed as having strep throat.

 

She was seen at a local hospital upon her return from Singapore, but appears to have been discharged. Two days later, with her conditioning worsening, she was admitted to a different hospital and then transferred to another facility, where the diagnosis of H5N1 was finally made on June 29th.

 

I’ve a machine translation from the announcement that appears on the Indonesian Ministry of Health website.

 

Bird Flu Case report 190

July 5, 2012 | 8:07 am

 

Ministry of Health, "Directorate General of Disease Control and Environmental Health" announced one new case of H5N1 have been confirmed by the Center for Basic Biomedical and Health Technology, Balitbangkes.

 

Case on behalf of the families (female, 8 years) who Falkirk District, West Java. On June 18, 2012 the case began to experience fever, June 19, the case went on holiday to Singapore and the next day for treatment didokter private practice, was diagnosed with strep throat.

 

On June 24, returned to Jakarta. June 25, the case went to the hospital. Falkirk District B with a complaint over a week heat, vomiting, cough, no appetite and was diagnosed with febrile and impairment of consciousness and no radiographic results Duplex bronchopneumonia.

 

June 26, forced to go home, then went to the hospital. S West Jakarta, the situation gets worse case then mounted ventilator and ICU admission, on June 28, referred to the RSP with the diagnosis of suspected bird flu, on June 29, the results of the sample by the Research and Development (BTDK) Positive H5N1.Kondisi case worsened and finally died world on July 3, 2012 at 22:45 pm.

 

Epidemiological investigations have been done to the house of the case, the environment, markets and hospitals where the case was referred to hospital were treated before referral FB (RSP). Acquired risk factors, namely the possibility of contact with poultry as before (date June 12) the case goes to market with his father and brother, bought 5 chickens living in which case the vote and cut the chicken in the poultry abattoir (TPU), the case also hold the chicken been deducted. Every day the case to the school through a new market Falkirk existing poultry seller.

 

With the increase of these cases, the cumulative number of bird flu in Indonesia since 2005 until this news was broadcast on 190 cases with 158 deaths.

 

Director General of Disease Control and Environmental Health Prof. dr. Tjandra Yoga Aditama as the focal point of the International Health Regulations (IHR) has been informed about the case to the WHO.

 

 

Today’s report is the first one we’ve seen out of Indonesia since early May.  The apparent CFR (Case Fatality Ratio), based on known cases in Indonesia, remains a sobering 83% (158 fatalities out of 190 cases).

 

The fact that this girl traveled to Singapore while actively infected will no doubt raise new concerns in the region over the ability of this virus to quietly cross borders.

 

While no additional transmission of the virus from this victim has been reported, this is the type of scenario that prompted Singapore to stockpile bird flu vaccine in 2010 (see Singapore Buys 1 Million H5N1 Shots).

 

Although we continue to see isolated human infections around the world, and the virus continues to evolve (see H5N1: An Increasingly Complex Family Tree), for now H5N1 is primarily a threat to poultry.

 

The concern, of course, is that over time that could change.

 

And so the world remains at Pre-pandemic Phase III on the H5N1 virus, and we continue to watch for signs that the virus is adapting better to humans.

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Singapore: H1N1 No Longer Dominant Strain

 



# 4749

 

 

A trend we’ve been watching for the past several months has been the persistence of seasonal H3N2 influenza in some regions of the world. 

 

The latest WHO update (week 26 – ending July 3rd) highlights the mixtures of laboratory typed flu strains from several reporting countries.  

 

As you can see, H3N2 continues to circulate in Mexico, Brazil, Argentina, South Africa, Australia, and parts of South East Asia.

 

image

 

Today we’ve a report (h/t Tetano on FluTrackers) from Singapore indicating that 45% of positive flu samples are coming back as H3N2.

 

H1N1 no longer dominant here

Fri, Jul 23, 2010

By Kenny Chee

THE Influenza A (H1N1) viral strain is no longer the dominant flu virus here, Singapore's Ministry of Health said yesterday.

 

And, since the strain has been found to be in the process of becoming seasonal in nature, Singapore and other Asean countries have stepped down, or are stepping down, their pandemic alert levels, said Health Minister Khaw Boon Wan.

 

The Health Ministry said that, as of last week, Influenza A (H1N1) comprised 31 per cent of all flu cases in the community here. But it is no longer the main circulating flu strain in Singapore, as it was as late as in May.

 

The seasonal strains, Influenza A (H3N2) and Influenza B, now constitute 45 per cent and 24 per cent of flu cases here, respectively.

 

In the last week of May, H1N1 accounted for 50 per cent of circulating strains, with the rest made up of H3N2 and Influenza B.

(Continue . . . )

 

 

Given the past history of pandemics, the future of H3N2 was in serious doubt a few months ago. 

 

In 1918, 1957, and again in 1968, the newly emerging pandemic strain managed to completely supplant the previously circulating A strains.

 

Flu Timeline

 

In 1977, however, the H1N1 virus reappeared after a 20 year absence – possibly due to an accidental laboratory release in the Soviet Union – and for the first time in modern history we had two influenza A strains (H3N2 and H1N1) in co-circulation.

 

Unlike novel H1N1, which largely spared the elderly over the past year, H3N2 has traditionally never been a respecter of age.  Years when H3N2 dominated have often produced more severe flu seasons.

 

Last year an antigenic change was detected in the H3N2 virus that may make prior exposure and/or vaccination less protective.

 

This fall’s vaccine has been reformulated to include antigens to this new strain.

 

Vaccination, while not 100% perfect, remains your best protection against the flu each year.

 

The future of H3N2, the mixture of flu viruses this fall, and the severity and impact of the upcoming flu season are far from certain at this date.  

 

Influenza is notoriously unpredictable, and we still appear to be in bit of a transition period.  One where the eventual viral winners and losers have yet to be sorted out.

 

Regardless of what the World Health Organization  decides on the status of the 2009 pandemic, this fall ought to provide us with ample opportunities to learn more about the evolution and spread of influenza viruses.

 

So stay tuned.

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AAMS: Pandemic Influenzas Edition

 

 

# 4579

 

 


The April, 2010 issue of Annals, Academy of Medicine, Singapore (AAMS) is devoted to Pandemic Influenzas, with more than a dozen editorials, research articles, cases series, and commentaries on the subject. 

 

ANNALS is open access, and so you can download and review each of these articles in their entirety.   They are for private use only, of course, and subject to copyright rules and certain restrictions.

 

This looks like an excellent resource, and as I get time to review some of these articles, I imagine I’ll find some fodder for a few blogs in the coming weeks.

 

The emergence of novel H1N1 will no doubt end up being the most studied public health event to date, and the next few years should bring a great deal more knowledge and understanding of the workings of a pandemic.

 

 

 

Editorial
The Influenza A (H1N1) 2009 Pandemic in Singapore
Li Yang Hsu, Derrick MK Heng, Yee Sin Leo

 

Original Articles
Pandemic (H1N1) 2009: Clinical and Laboratory Findings of the First Fifty Cases in Singapore
Monica Chan, Mark I Chen, Angela Chow, Caroline PS Lee, Adriana SH Tan, David Chien Lye, Yee Sin Leo

Outbreak of Pandemic Influenza A (H1N1-2009) in Singapore, May to September 2009
Jeffery L Cutter, Li Wei Ang, Florence YL Lai, Hariharan Subramony, Stefan Ma, Lyn James

An Epidemiological Study of 1348 Cases of Pandemic H1N1 Influenza Admitted to Singapore Hospitals from July to September 2009
Hariharan Subramony, Florence YL Lai, Li Wei Ang, Jeffery L Cutter, Poh Lian Lim, Lyn James

Tracking the Emergence of Pandemic Influenza A/H1N1/2009 and its Interaction with Seasonal Influenza Viruses in Singapore
Julian WT Tang, Chun Kiat Lee, Hong Kai Lee, Tze Ping Loh, Lily Chiu, Paul A Tambyah, Evelyn SC Koay

Obstetric Outcomes of Influenza A H1N1 (2009) Infection in Pregnancy – Experience of a Singapore Tertiary Hospital
May Li Lim, Wai Yee Lim, Nancy WS Tee, Siok Hong Lim, Jing Jye Chee

Outbreak of Novel Influenza A (H1N1-2009) Linked to a Dance Club
Pei Pei Chan, Hariharan Subramony, Florence YL Lai, Wee Siong Tien, Boon Hian Tan, Suhana Solhan, Hwi Kwang Han, Bok Huay Foong, Lyn James, Peng Lim Ooi

Attitudes of Patients, Visitors and Healthcare Workers at a Tertiary Hospital Towards Influenza A (H1N1) Response Measures
Wu Meng Tan, Nidhi Loomba Chlebicka, Ban Hock Tan

Survey of Healthcare Workers’ Attitudes, Beliefs and Willingness to Receive the 2009 Pandemic Influenza A (H1N1) Vaccine and the Impact of Educational Campaigns
Koh Cheng Thoon, Chia Yin Chong

 

Review Article
Influenza A (H1N1-2009) Pandemic in Singapore – Public Health Control Measures Implemented and Lessons Learnt
Joanne Tay, Yeuk Fan Ng, Jeffery Cutter, Lyn James

 

Short Communication
International Health Regulations: Lessons from the Influenza Pandemic in Singapore
Chew Ling Low, Pei Pei Chan, Jeffery L Cutter, Bok Huay Foong, Lyn James, Peng Lim Ooi

 

Case Series
Severe Infection with H1N1 Requiring Intensive Care – Lessons for Preparedness Programmes
Jaime MF Chien, Ban Hock Tan, Kok Soong Yang, Thuan Tong Tan, Chian Yong Low, Asok Kurup, Hoe Nam Leong, Jenny GH Low, Mei Ling Kang, Maciej Piotr Chlebicki, Yin Ling Koh

 

Commentaries
2009 Pandemic Influenza H1N1: Paediatric Perspectives
Hao Yuan Lee, Chang Teng Wu, Tzou Yien Lin, Cheng Hsun Chiu

Surveys of Knowledge, Attitudes and Practices on the Influenza A (H1N1) Pandemic
Li Yang Hsu

 

Letters to the Editor
Streptococcus pneumoniae Bacteraemia in a Young Man with Pandemic Influenza A (H1N1) 2009
Florante S Isais, Frederico Dimatactac, Ryan Llorin, Angela Chow, Yee Sin Leo

Use of Healthcare Worker Sickness Absenteeism Surveillance as a Potential Early Warning System for Influenza Epidemics in Acute Care Hospitals
Sapna Sadarangani, Mark IC Chen, Angela LP Chow, Arul Earnest, Mar Kyaw Win, Brenda SP Ang

 

Afterword
Jeffery L Cutter

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Singapore Buys 1 Million H5N1 Shots

 

 

 

# 4423

 

 

Singapore is an island city-state located on the tip of the Malay Peninsula, with nearly 5 million inhabitants.    It is one of only three present day sovereign city-states, the other two being The Vatican and Monaco.

 

Long considered The Crossroads of the Orient, Singapore is literally  surrounded by countries that have seen outbreaks of H5N1 bird flu in poultry and sporadic cases in humans.  

 

Singapore

 

Their proximity to Indonesia, Malaysia, Cambodia, Vietnam, and Thailand is enough to give them pause, knowing that a pandemic outbreak in any of these neighboring countries would likely spill over to them in short order.

 

Consequently Singapore has been very active in making pandemic preparations (see In The Wake Of SARS, Singapore Prepares), and has recently ordered 1 million doses of H5N1 vaccine for their national stockpile.

 

Since vaccines have a limited shelf life (18 months to 2 years), making this sort of financial commitment is not an easy decision.  Their move to stockpile vaccine illustrates that - while largely absent from U.S. newspaper headlines - concerns over the bird flu virus have not gone away.

 

This report from  The Straits Times.

 

 
S'pore buys 1m H5N1 shots
March 12, 2010
H5N1 bug could be a bigger killer than H1N1 if it mutates

By Salma Khalik, Health Correspondent

SINGAPORE has bought a million doses of a vaccine to protect the people here against the H5N1 bird flu.

 

The vaccine will arrive by the end of the year.

 

The bug is particularly scary for Singapore, which sits next to Indonesia, the country with the most cases (163) and deaths (135) from the virus. Vietnam, with the next highest number of cases (115) and deaths (58), is also nearby.

 

Both countries have already had one death each this year.

 

Unlike the H1N1 pandemic that swept the globe last year, the H5N1 bug could be a bigger killer by far if it mutates.

 

Of the 486 people reported to have been infected by H5N1 since 2003, 287 have died. This works out to an almost six-in-10 death rate.

 

»» Read More

Singapore To Stockpile Bird Flu Vaccine

 

 

 

# 4303

 

 

image

 



While the H5N1 bird flu virus has thus far not managed to adapt to humans well enough to spread among them easily, there are scientists and governments around the world who believe that may still happen.   

 

With a CFR (Case Fatality Ratio) that has run 50% or greater in some countries, an outbreak would be far worse than anything the H1N1 virus has produced.  

 

Although the probability of this happening is unknown, having a vaccine on hand would greatly reduce the impact of an outbreak.

 

Singapore, with a population of roughly 5 million and neighbor to bird flu endemic Indonesia, is looking to stockpile roughly 1 million doses of H5N1 vaccine.

 

This is a bit of a gamble, of course, since vaccines have a limited shelf life; generally 18 months to 2 years.  

 

This from the Singapore Times.

 

 

Jan 29, 2010

1m doses of bird flu vaccine

 

By Jessica Jaganathan

THE Health Ministry will be buying about one million doses of H5N1 avian flu pre-pandemic vaccine soon.

 

Health Minister Khaw Boon Wan revealed yesterday that his ministry is evaluating a tender to stock up on the vaccine.

 

'It's one of those insurance policies that we have to buy and we will stock it up and hope never to have to use it,' he said.

 

'The virus is still out there and it may flare up, so we cannot afford not to do anything.'

 

The World Health Organisation's director-general, Dr Margaret Chan, had recently said that countries remain ill-prepared for mass outbreaks of the bird flu virus, which affects humans in contact with sick birds.

 

It has a mortality rate of more than 60 per cent, leading to fears that a pandemic with this strain of virus could prove lethal. Scientists also fear that it could achieve efficient human-to-human transmission at any time and trigger a pandemic.

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